JM, I had success with SamE when I was feeling very mildly anxious and depressed but it did not help when I was more anxious/depressed. Also, with SamE the results were gained from starting at a higher dose than what is typically listed on the package so check on line before starting it. Also, I forget which one, SamE or St. John's has interactions with some meds so check that out too. It has to be out of your system for a certain length of time before taking meds and can't be taken together with them. I never tried Kava because a co-worker took it for anxiety and it seemed to increase hers. That scared me. Rachele