Yes, I take Xanax XR - 0.5 mg a day - which is a very small dose, but all I need. I had taken the regular Xanax and had my reservations about taking the XR, but it has worked out wonderfully. No more roller coaster emotional ride or watching the clock for when I can take the next one. It did take me a while to tweak the best time for me to take mine. They do not give that immediate relief feel of the regular ones. I take mine at my least anxious time, around lunch time, so that during the afternoon and evening and next morning I have full coverage. I had been taking them late afternoon, but found that I was "losing" my best coverage while sleeping! Play with when you take them - that works. Will your Dr. allow you take a regular Xanax for times when you have an attack? I still have the regular Xanax as well, for emergencies, but in 3 months of being on the XR, I've only used one pill. They really do work. Let your mind believe they do - it is hard when you already have something that works, but it really is much easier this way. Take care and keep me posted. Kelly

Hi, I don't take Xanax but thought u may want to read this report about mixing Xanax with grapefruit juice: Indeed, grapefruit juice reacts with Xanax (alprazolam). This is an example of a drug-beverage interaction that mainly occurs in the liver. Before I go on to the details of this drug-beverage interaction, allow me to give a brief review of the liver metabolism of drugs. Every time we ingest a medication or other substances, 4 body processes are involved to convert this substance into an inactive and water-soluble product for elimination. These processes are absorption, distribution, metabolism, and elimination. Drug-drug or drug-food/herbs interactions can occur in any of theses processes but majority of them involve the liver metabolism. Every time a drug is added to a regularly taken drug, drug-drug interactions are bound to occur. Fortunately, most of these interactions are subtle or clinically insignificant, but some can be serious and even deadly. In the liver, there are several liver enzymes (mainly called cytochrome enzymes) involved in the metabolism (break down) of drugs and other substances. There are 5 major liver enzymes or cytochrome enzymes that are primarily involved in the metabolism of most drugs including the psychotropics. Drugs that depend on a specific liver enzyme for metabolism are called "substrates" of that enzyme. As there are "substrates" of a specific liver enzyme, there are also drugs that inhibit or antagonize the action of a specific liver enzyme, and drugs that stimulate or activate the action of a specific liver enzyme. Drugs that inhibit the action of a specific liver enzyme are called "inhibitors" of that enzyme; those that activate or stimulate the action of a specific liver enzyme are called "inducers" of that enzyme. Enzyme inhibition leads to decreased metabolism of drugs that depend on this enzyme, leading to increased blood level and side effects. On the other hand, enzyme induction or activation leads to increased metabolism of drugs that depend on this enzyme, leading to decreased in blood level and loss of effectiveness. Xanax is a substrate of the liver enzyme called cytochrome P450 3A4 or CYP3A4 for short. This means that Xanax mainly depends on this liver enzyme for its metabolism. G

I was wondering if anyone out there has tried Xanax XR. I just started taking them on Monday. I have been taking regular Xanax for a while and my doctor suggested the XR along with 37.5 mgs of Effexor XR. I had the regular Xanax down to a science (when they would take effect, when it would start to wear off, etc.). I'm not sure how these new extended release tablets work. Do you need to take them for awhile before you have an even level in your blood stream, or do they start to work right away? I'm asking because I had such bad anxiety this morning on my way to work. I had taken a pill about 20 min. before I left the house, and by the way I felt on my commute, they obviously hadn't taken effect yet. I would love some feedback from anyone who is on this medication.