I am glad I came across this message, I have been on most of the major depression medicines and I also have severe fibromyalgia, I believe its the cause of my depression. I went from 135 pounds start of my pregnancy to 264 and delievered a month early. I had severe toximia, also known as toximia. I was hospitalized several times and put on complete bedrest at 5 months, my body was so full of poison, it was terrible, since delivery, I have been in severe pain, times undescribable. I heard about Cymbalta helping relieve fibro symptoms. Since starting it, I have been having severe headaches, I suffer from migraines, I am on 20 mg for 1 wk, then 40 mg there after. After 4 days of being on it, the insomnia terrible, I tend on getting some benadryl or tylenol pm and see how that goes but my headache is constant. I was getting ready to stop taking it and contact my dr, thinking it wasnt going to get better. After reading some of the replies I now have hope that they will fade. So..wish me luck, Cindy